ON HUMAN “EDITING”: CALIBRATION OF A METAPHOR

© 2021 Sergei Valerievich Sokolovsky

2021 – № 2 (22)


DOI: https://doi.org/10.33876/2224-9680/2021-2-22/11

Citation link: 

Sokolovsky S. V. (2021). O ‘redaktirovanii’ cheloveka: kalibrovka metafory [About Human “Editing”: Calibration of a Metaphor]. Medicinskaja antropologija i biojetika [Medical Anthropology and Bioethics], 2 (22).


Author info:

Sergei Valerievich Sokolovsky, Dr. Hist. Sc., is a Chief Research Fellow at the Institute of Ethnology and Anthropology (Russian Academy of Sciences, Moscow).


Keywords: genome manipulations (genetic “editing”), human genome, “genetic scissors”, CRISPR-Cas9, metaphorics, popularization of scientific knowledge

Abstract. The article focuses on the metaphorics used in academic and non-fiction literature that addresses the topic of the human genome “editing”. Apart from the metaphor of editing, the review touches upon the metaphors of genome mapping, gene as a target (the metaphor of targeting), the organism as a machine, etc. Because the choice of metaphors is a key aspect in public perception of scientific discoveries, the one that conditions public approval or blocking of new directions of the scientific quest, thorough analysis, and elaboration of metaphoric means are necessary, so they convey the complicated scientific data. Equally necessary is fine-tuning of stylistic tropes used for science popularization.


References

Avise, J.C. (2001) Evolving genomic metaphors: A new look at the language of DNA. Science, N 294 (5540), p. 86–87.

Balmer, A., Herreman, C. (2009) Craig Venter and the re-programming of life: How metaphors shape and perform ethical discourses in the media presentation of synthetic biology. B. Nerlich, R. Elliott, and B.Larson (eds.), Communicating biological sciences: Ethical and metaphorical dimensions, Aldershot: Ashgate, p. 219–234.

Boldt, J. (2016) Synthetic Biology. Metaphors, worldviews, ethics, and law. Berlin: Springer VS.

Boudry, M., Pigliucci, M. (2013) The mismeasure of machine: Synthetic biology and the trouble with engineering metaphors. Stud. Hist. Philos. Biol. Biomed. Sci., N 44 (4), p. 660–668.

Charo, R.A., Greely, H.T. (2015) CRISPR critters and CRISPR cracks. American Journal of Bioethics, N 15 (12), p. 11–17.

Davidson, Donald (1978) What Metaphors Mean. Critical Inquiry, N 5, p. 31–47 (русский перевод в: Теория метафоры. М.: Прогресс, 1990, c. 173–193).

de Lorenzo, V. (2011) Beware of metaphors: Chasses and orthogonality in synthetic biology. Bioengineered bugs, N 2 (1), p. 3–7.

Döring, M. (2014) Metaphorische Moral in aktuellen biotechnologischen Diskursen. Matthias Junge (Hrsg.). Methoden der Metaphernforschung und –analyse, Berlin: Springer VS, p. 215–229.

Falkner, D. (2016) Metaphors of life: Reflections on metaphors in the debate on synthetic biology, K. Hagen, M. Engelhard, and G. Toepfer (eds.), Ambivalences of creating life: Societal and philosophical dimensions of synthetic biology, Heidelberg: Springer International, p. 251–265.

Hellsten, I., Nerlich, B. (2008) Genetics and genomics: The politics and ethics of metaphorical framing, M. Bucchi and B. Trench (eds.), Handbook of public communication of science and technology, London; New York: Routledge, p. 93–109.

Hellsten, I., Nerlich, B. (2011) Synthetic biology: Building the language for a new science brick by metaphorical brick, New Genetics and Society. N 30 (4), p. 375–397.

Keller, E.F. (2002) Making sense of life: Explaining biological development with models, metaphors, and machines. Cambridge, MA: Harvard University Press.

Kueffer, Chr.; Larson, B. M. (2014) Responsible use of language in scientific writing and science communication. BioScience, biu084.

Mauricio, R. (2005) Can ecology help genomics: The genome as eco-system? Genetica, N 123, p. 205–209.

Merriman, B. (2015) ‘Editing’: A Productive Metaphor for Regulating CRISPR. American Journal of Bioethics, N 15 (12), p. 62–64. DOI: 10.1080/15265161. 2015.1103806.

McLeod, C., Nerlich, B. (2017) Synthetic biology, metaphors and responsibility. Life Sciences, Society and Policy, N 13, p. 13. DOI 10.1186/s40504-017-0061-y.

Nelkin, D., Lindee, S. (2004) The DNA mystique: The gene as a cultural icon. Ann Arbor: Univ. of Michigan press.

Nelson, S.C., Yu, J.-H., and Ceccarelli, L. (2015) How metaphors about the genome constrain CRISPR metaphors: Separating the ‘text’ from its ‘editor’. American Journal of Bioethics, N 15 (12), p. 60–62.

Nerlich, B., Hellsten, I. (2004) Genomics: Shifts in metaphorical landscape. New Genetics and Society, N 23 (3), p. 255–268.

Nerlich, B., Hellsten, I. (2009) Beyond the human genome: Microbes, metaphors and what it means to be human in an interconnected post-genomic world. New Genetics and Society, N 28 (1), p. 19–36.

O’Keefe, M., Perrault, S., Halpern, J., Ikemoto, L, Yarborough, M., and UC North Bioethics Collaboratory for Life & Health Sciences (2015) Editing genes: A case study about how language matters in bioethics. American Journal of Bioethics, N 15 (12), p. 3–10.

Pauwels, E. (2013) Comment: Mind the metaphor, Nature, vol. 500 (29 August), p. 523–524.

Zwart, H. (2009a) Genomics metaphors and genetic determinism, A.M. Martin, F.W. Drenthen, J. Keulartz, and J. Proctor (eds.), New visions of nature: complexity and authenticity, Netherlands: Springer, p. 155–172.

Zwart, H. (2009b) The adoration of a map: Reflections on a genome metaphor. Genomics, Society & Policy, N 5 (3), p. 29–43.